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Article

Biochemical characterization of the type I inositol polyphosphate 4-phosphatase C2 domain.

Biochemical and biophysical research communications - 27 Apr 2007

Shearn Colin T, Norris F Anderson

Abstract excerpt

Inositol polyphosphate 4 phosphatases (IP4Ps) are enzymes involved in the regulation of phosphoinositide 3-kinase lipid signaling. They catalyze the hydrolysis of the 4-position phosphate from phosphatidylinositol 3,4-bisphosphate to phosphatidylinositol 3-phosphate. In this paper we have characterized a lipid binding C2 domain located on the N-terminus of type I IP4Ps. Mutational analysis of the lipid binding...

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PMID: 17349979
DOI: 10.1016/j.bbrc.2007.02.115

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