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Article

Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents.

Genes, chromosomes & cancer - 1 Oct 1998

Levati L, Marra G, Lettieri T, D'Atri S, Vernole P, Tentori L, Lacal P M, Pagani E, Bonmassar E, Jiricny J, Graziani G

Abstract excerpt

Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O6 position of guanine. These methyl adducts are removed from DNA by the O6-alkylguanine DNA alkyltransferase (OGAT). The mechanism by which O6-methylguanine (O6meG) induces cell death in OGAT-deficient cells requires a functional mismatch repair system (MRS). We have previously reported that depletion of OGAT...

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PMID: 9739019

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CGA

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents.PMID 9739019Read ↗

Defective mismatch binding and a mutator phenotype in cells tolerant to DNA damage.Semantic proximity Read ↗

hMutSα- and hMutLα-dependent phosphorylation of p53 in response to DNA methylator damageSemantic proximity Read ↗

A mutator phenotype characterizes one of two complementation groups in human cells tolerant to methylation damage.Semantic proximity Read ↗

DNA mismatch repair mutants do not increase N-methyl-N'-nitro-N-nitrosoguanidine tolerance in O6-methylguanine DNA methyltransferase-deficient yeast cells.Semantic proximity Read ↗

Genomic instability and tolerance to alkylating agents.Semantic proximity Read ↗

hMSH2 forms specific mispair-binding complexes with hMSH3 and hMSH6Semantic proximity Read ↗

Functional overlap in mismatch repair by human MSH3 and MSH6.Semantic proximity Read ↗

Increased somatic recombination in methylation tolerant human cells with defective DNA mismatch repair.Semantic proximity Read ↗

Phosphorylated hMSH6: DNA mismatch versus DNA damage recognition.Semantic proximity Read ↗

Complementation of mismatch repair gene defects by chromosome transfer.Semantic proximity Read ↗

Differential involvement of the human mismatch repair proteins, hMLH1 and hMSH2, in transcription-coupled repair.Semantic proximity Read ↗

Mismatch repair deficiency associated with overexpression of the <i>MSH3</i> geneSemantic proximity Read ↗

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