Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents.

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Article

Mutation of the mismatch repair gene hMSH2 and hMSH6 in a human T-cell leukemia line tolerant to methylating agents.

Genes, chromosomes & cancer - 1 Oct 1998

Levati L, Marra G, Lettieri T, D'Atri S, Vernole P, Tentori L, Lacal P M, Pagani E, Bonmassar E, Jiricny J, Graziani G

Abstract excerpt

Cell killing by monofunctional methylating agents is due mainly to the formation of adducts at the O6 position of guanine. These methyl adducts are removed from DNA by the O6-alkylguanine DNA alkyltransferase (OGAT). The mechanism by which O6-methylguanine (O6meG) induces cell death in OGAT-defic...

Topics

Base Pair Mismatch
DNA Methylation
DNA Repair
DNA-Binding Proteins
Drug Resistance, Neoplasm
Humans
Jurkat Cells
Leukemia, T-Cell
MutS Homolog 2 Protein
Mutation
Proto-Oncogene Proteins
Tumor Cells, Cultured

Source

Open in PubMed

Identifiers

PMID: 9739019

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9739019-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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