Genetic alterations in gallbladder adenoma, dysplasia and carcinoma.

doi:10.1016/s0304-3835(01)00562-6

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Article

Genetic alterations in gallbladder adenoma, dysplasia and carcinoma.

Cancer letters - 10 Aug 2001

Kim Y T, Kim J, Jang Y H, Lee W J, Ryu J K, Park Y K, Kim S W, Kim W H, Yoon Y B, Kim C Y

Abstract excerpt

Adenoma and dysplasia in the gallbladder (GB) have been reported as precancerous lesions, but the genetic evidence of this is not clearly defined. The purpose of this study was to analyze the frequencies of K-ras, p53, and p16 gene mutations, of microsatellite instability (MI) and of loss of heterozygosity (LOH) in GB cancer, dysplasia, and adenoma. Tissues from 15 GB cancers, five dysplasias around cancerous...

Topics

Adenoma
Adult
Aged
Carcinoma
Cyclin-Dependent Kinase Inhibitor p16
DNA, Neoplasm
Female
Gallbladder
Gallbladder Neoplasms
Genes, p16
Genes, p53
Genes, ras
Humans
Immunohistochemistry
Loss of Heterozygosity

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Open in PubMed

Identifiers

PMID: 11410326
DOI: 10.1016/s0304-3835(01)00562-6

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Male

Microsatellite Repeats

Middle Aged