Article
Genetic abnormalities involved in the pathogenesis of gallbladder carcinoma.
Journal of hepato-biliary-pancreatic surgery - 1 Jan 1999
Wistuba I I, Albores-Saavedra J
Abstract excerpt
While considerable progress has been made in the understanding of the genetic changes involved in the pathogenesis of several human neoplasms, there is limited information about the genetic changes involved in the development of gallbladder carcinoma. Several studies indicate that TP53 (17p13) and p16(Ink4)/CDKN2 (9p21-22) gene loci abnormalities are frequent and early events in the pathogenesis of this neoplasm,...
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