Article
Allelotype analysis of gallbladder carcinoma associated with anomalous junction of pancreaticobiliary duct.
Cancer letters - 26 May 2001
Nakayama K, Konno M, Kanzaki A, Morikawa T, Miyashita H, Fujioka T, Uchida T, Miyazaki K, Takao S, Aikou T, Fukumoto M, Takebayashi Y
Abstract excerpt
Anomalous junction of pancreaticobiliary duct (AJPBD) patients has an increased risk of gallbladder and bile duct carcinomas. However, the relevance of carcinoma with AJPBD is not fully clarified. We performed analysis of loss of heterozygosity (LOH) at p53 locus and immunohistochemistry of p53 and K-ras gene mutation in five cases of gallbladder carcinoma associated with AJPBD. LOH of p53 locus and...
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