Sequential Occurrence of Preneoplastic Lesions and Accumulation of Loss of Heterozygosity in Patients With Gallbladder Stones Suggest Causal Association With Gallbladder Cancer

Abstract excerpt

In Brief Background: Causal association of gallbladder stones with gallbladder cancer (GBC) is not yet well established. Objective: To study the frequency of occurrence of preneoplastic histological lesions and loss of heterozygosity (LOH) of tumor suppressor genes in patients with gallstones. Methods: All consecutive patients with gallstones undergoing cholecystectomy from 2007–2011 were included prospectively....

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