In vitro stimulation of ovarian tumour-associated lymphocytes with a peptide derived from HER2/neu induces cytotoxicity against autologous tumour.

doi:10.1016/s0960-7404(10)80030-1

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Article

In vitro stimulation of ovarian tumour-associated lymphocytes with a peptide derived from HER2/neu induces cytotoxicity against autologous tumour.

Surgical oncology - 1 Feb 1995

Linehan D C, Peoples G E, Hess D T, Summerhayes I C, Parikh A S, Goedegebuure P S, Eberlein T J

Abstract excerpt

The proto-oncogene HER2/neu encodes for a 185 kDa transmembrane protein with extensive homology to the epidermal growth factor (EGF) receptor. We have previously shown a correlation between HER2/neu expression and the level of in vitro cytotoxicity of tumour-associated lymphocytes (TAL) versus autologous tumour. In addition, we have recently demonstrated that tumour-associated cytotoxic T-lymphocytes (CTL) from...

Topics

Adenocarcinoma
Antibodies, Monoclonal
Base Sequence
Cytotoxicity, Immunologic
DNA, Complementary
DNA, Neoplasm
Female
HLA-A2 Antigen
Humans
Interleukin-2
Lymphocytes, Tumor-Infiltrating

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Ovarian Neoplasms

Peptide Fragments

Phenotype

Polymerase Chain Reaction

Proto-Oncogene Mas

Receptor, ErbB-2

Source

Open in PubMed

Identifiers

PMID: 7780612
DOI: 10.1016/s0960-7404(10)80030-1

Genes

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7780612-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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In vitro stimulation of ovarian tumour-associated lymphocytes with a peptide derived from HER2/neu induces cytotoxicity against autologous tumour.PMID 7780612Read ↗

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