Article
Familial head and neck cancer: molecular analysis of a new clinical entity.
The Laryngoscope - 1 Sept 2002
Yu Kathy K, Zanation Adam M, Moss Jonathan R, Yarbrough Wendell G
Abstract excerpt
OBJECTIVE: The tumor suppressor gene p16 encodes a cyclin-dependent kinase inhibitor that normally inhibits cell proliferation by causing a G1 cell cycle arrest. The p16 gene is frequently mutated in a variety of somatic tumors, as well as in familial melanoma and familial pancreatic carcinoma. We identified a family with a high incidence of head and neck squamous cell carcinoma (HNSCC) and melanoma. Molecular...
Topics
- Alleles
- Amino Acid Substitution
- Carcinoma, Squamous Cell
- Cyclin-Dependent Kinase Inhibitor p16
- Exons
- Family Health
- Flow Cytometry
- Gene Expression
- Genes, Tumor Suppressor
- Genetic Predisposition to Disease
- Germ-Line Mutation
- Head and Neck Neoplasms
- Humans
- Melanoma
- Pedigree
- Polymerase Chain Reaction