Article
Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.
Molecular and cellular biology - 1 Jul 1996
Parry D, Peters G
Abstract excerpt
Altered expression or function of the p16CDKN2 tumor suppressor gene on chromosome 9p21 occurs in a wide range of human tumors, and mutations in the gene have been shown to segregate with familial predisposition to malignant melanoma. We have used a variety of assays to examine the functional pro...
Topics
- Bone Neoplasms
- Carrier Proteins
- Cell Line
- Chromosome Mapping
- Chromosomes, Human, Pair 9
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Enzyme Inhibitors
- Genes, Tumor Suppressor
- Genetic Variation
- Humans
- Melanoma
- Mutagenesis, Site-Directed
- Mutation
- Osteosarcoma
- Point Mutation
- Protein Biosynthesis