Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.

Molecular and cellular biology - 1 Jul 1996

Parry D, Peters G

Abstract excerpt

Altered expression or function of the p16CDKN2 tumor suppressor gene on chromosome 9p21 occurs in a wide range of human tumors, and mutations in the gene have been shown to segregate with familial predisposition to malignant melanoma. We have used a variety of assays to examine the functional properties of tumor-associated alleles, including eight premature termination mutants, eight missense mutants, and three...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Carrier Proteins
Share to Cell Line
Share to Chromosome Mapping

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Variation

Share to Mutagenesis, Site-Directed

Share to Mutation

Share to Point Mutation

Share to Protein Biosynthesis

Source

Open in PubMed Open full text

Identifiers

PMID: 8668202
DOI: 10.1128/MCB.16.7.3844
PMCID: PMC231381

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Temperature-sensitive mutants of p16CDKN2 associated with familial melanoma.PMID 8668202Read ↗

Tumour-derived p16 alleles encoding proteins defective in cell-cycle inhibition.Semantic proximity Read ↗

Mutation of the CDKN2A 5' UTR creates an aberrant initiation codon and predisposes to melanoma.Semantic proximity Read ↗

Functional, structural, and genetic evaluation of 20<i>CDKN2A</i>germ line mutations identified in melanoma-prone families or patientsSemantic proximity Read ↗

Compilation of somatic mutations of the CDKN2 gene in human cancers: non-random distribution of base substitutions.Semantic proximity Read ↗

CDKN2A (p16INK4A) somatic and germline mutations.Semantic proximity Read ↗

Functional evaluation of tumour-specific variants of p16INK4a/CDKN2A: correlation with protein structure information.Semantic proximity Read ↗

A rare germline CDKN2A variant (47T>G; p16-L16R) predisposes carriers to pancreatic cancer by reducing cell cycle inhibition.Semantic proximity Read ↗

Functional analysis of CDKN2A/p16INK4a 5'-UTR variants predisposing to melanoma.Semantic proximity Read ↗

Virtually 100% of melanoma cell lines harbor alterations at the DNA level within CDKN2A, CDKN2B, or one of their downstream targets.Semantic proximity Read ↗

Melanoma development in relation to non-functional p16/INK4A protein and dysplastic naevus syndrome in Swedish melanoma kindreds.Semantic proximity Read ↗

CDKN2A and CDK4 mutation analysis in Italian melanoma-prone families: functional characterization of a novel CDKN2A germ line mutationSemantic proximity Read ↗

Germline mutations in the p16INK4a binding domain of CDK4 in familial melanomaSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.