Article
Functional impairment of melanoma-associated p16(INK4a) mutants in melanoma cells despite retention of cyclin-dependent kinase 4 binding.
Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Oct 2001
Becker T M, Rizos H, Kefford R F, Mann G J
Abstract excerpt
PURPOSE: Melanoma-associated germ-line mutations affecting the tumor suppressor and cyclin-dependent kinase (CDK) inhibitor, CDKN2A/p16(INK4a) have been identified in >100 melanoma-prone families. To predict the melanoma risk for carriers of specific mutations, it is useful to test the function of the mutant proteins in biochemical assays; however, it is unclear how well these results correlate with their...
Topics
- Cell Division
- Cyclin-Dependent Kinase 4
- Cyclin-Dependent Kinase Inhibitor p16
- Cyclin-Dependent Kinases
- Gene Expression Regulation, Neoplastic
- Genotype
- Humans
- Melanoma
- Mutation
- Protein Binding
- Proto-Oncogene Proteins
- Recombinant Fusion Proteins
- Tumor Cells, Cultured