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Article

Expression of tal-1 and GATA-binding proteins during human hematopoiesis

1 Feb 1993

Abstract excerpt

Tal-1 rearrangements are associated with nearly 30% of human T acute lymphoblastic leukemia. Tal-1 gene encodes a putative transcription factor with a basic helix-loop-helix domain and is known to be predominantly expressed in hematopoietic cells. We investigated the pattern of tal-1 expression in purified human hematopoietic cells by in situ hybridization and reverse transcriptase polymerase chain reaction...

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PMID: 7678994
DOI: 10.1182/blood.v81.3.647.647

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