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Article

Effects of anti-tal-1 oligodeoxynucleotides in T-ALL cell lines.

Cancer gene therapy - 1 Jan 2000

Anderegg B, Horstmann M, Kabisch H

Abstract excerpt

Rearrangement of the gene tal-1 leads to transcriptional dysregulation and contributes to the formation of childhood T-cell acute lymphoblastic leukemia. Therefore, we tried to interfere with the transcription of the SIL/tal-1 fusion gene, the most common form of aberrant tal-1, by treatment with antisense oligodeoxynucleotides (ODNs). The potential of two different strategies was investigated, one targeting the...

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Identifiers

PMID: 9080116

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Effects of anti-tal-1 oligodeoxynucleotides in T-ALL cell lines.PMID 9080116Read ↗

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Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.Semantic proximity Read ↗

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Rearrangements of the tal-1 locus as clonal markers for T cell acute lymphoblastic leukemia.Semantic proximity Read ↗

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