Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.

doi:10.1038/31008

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Article

Role of Mxi1 in ageing organ systems and the regulation of normal and neoplastic growth.

Nature - 4 Jun 1998

Schreiber-Agus N, Meng Y, Hoang T, Hou H, Chen K, Greenberg R, Cordon-Cardo C, Lee H W, DePinho R A

Abstract excerpt

Mxi1 belongs to the Mad (Mxi1) family of proteins, which function as potent antagonists of Myc oncoproteins. This antagonism relates partly to their ability to compete with Myc for the protein Max and for consensus DNA binding sites and to recruit transcriptional co-repressors. Mad(Mxi1) proteins...

Topics

Aging
Animals
Basic Helix-Loop-Helix Transcription Factors
Cell Division
Cell Transformation, Neoplastic
DNA-Binding Proteins
Genes, Tumor Suppressor
Kidney
Male
Mice
Neoplasms
Organ Specificity
Phenotype
Prostate
Transcription Factors
Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 9624006
DOI: 10.1038/31008

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9624006-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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