Article
Mxi1 tumor suppressor gene is not mutated in primary pancreatic adenocarcinoma.
Cancer letters - 19 Apr 1996
Bartsch D, Peiffer S L, Kaleem Z, Wells S A, Goodfellow P J
Abstract excerpt
Amplification of the c-myc oncogene occurs in a variety of solid tumors, including pancreatic adenocarcinomas. The MXI1 gene, located at 10q24-q25, may serve to negatively regulate c-myc oncogene activity, and potentially has tumor suppressor function. As such, altered MXI1 function might contrib...
Topics
- Adenocarcinoma
- Basic Helix-Loop-Helix Transcription Factors
- Blotting, Southern
- Carcinoma, Ductal, Breast
- DNA, Neoplasm
- DNA-Binding Proteins
- Genes, Tumor Suppressor
- Genes, myc
- Humans
- Mutation
- Pancreatic Neoplasms
- Transcription Factors