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<i>KAI1</i> , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2

12 May 1995

Abstract excerpt

A gene from human chromosome 11p11.2 was isolated and was shown to suppress metastasis when introduced into rat AT6.1 prostate cancer cells. Expression of this gene, designated KAI1, was reduced in human cell lines derived from metastatic prostate tumors. KAI1 specifies a protein of 267 amino acids, with four hydrophobic and presumably transmembrane domains and one large extracellular hydrophilic domain with...

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PMID: 7754374
DOI: 10.1126/science.7754374

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<i>KAI1</i> , a Metastasis Suppressor Gene for Prostate Cancer on Human Chromosome 11p11.2PMID 7754374Read ↗

Down-regulation of the KAI1 metastasis suppressor gene during the progression of human prostatic cancer infrequently involves gene mutation or allelic loss.Semantic proximity Read ↗

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KAI1, a putative marker for metastatic potential in human breast cancerSemantic proximity Read ↗

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KAI1 COOH-Terminal Interacting Tetraspanin (KITENIN), a Member of the Tetraspanin Family, Interacts with KAI1, a Tumor Metastasis Suppressor, and Enhances Metastasis of CancerSemantic proximity Read ↗

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Genomic Organization, Expression, and Chromosome Localization of a Third Aurora-Related Kinase Gene, <i>Aie1</i>Semantic proximity Read ↗

Functional identification of LZTS1 as a candidate prostate tumor suppressor gene on human chromosome 8p22Semantic proximity Read ↗

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