Article
The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.
Oncology reports - 1 Jan 2000
Kuczyk M A, Serth J, Bokemeyer C, Schwede J, Herrmann R, Machtens S, Grünewald V, Höfner K, Jonas U
Abstract excerpt
For prostate cancer, allelic deletions from the long arm of chromosome 10 (#10q23-25), the locus of the putative tumor suppressor gene MXI1 (#10q24-25), have been identified as a frequently occurring genetic event. During the development of several human malignancies, the c-myc proto-oncogene has...
Topics
- Adenocarcinoma
- Alleles
- Basic Helix-Loop-Helix Transcription Factors
- Chromosome Mapping
- Chromosomes, Human, Pair 10
- DNA Primers
- DNA-Binding Proteins
- Exons
- Gene Deletion
- Genes, Tumor Suppressor
- Helix-Loop-Helix Motifs
- Humans
- Male
- Mutation
- Neoplasm Staging
- Polymerase Chain Reaction
- Prostatic Neoplasms
- Proto-Oncogene Mas