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Article

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.

International journal of cancer - 15 Nov 2000

Wang D S, Rieger-Christ K, Latini J M, Moinzadeh A, Stoffel J, Pezza J A, Saini K, Libertino J A, Summerhayes I C

Abstract excerpt

Loss of heterozygosity (LOH) on 10q is associated with late-stage events in urothelial neoplastic progression. The tumor suppressor gene PTEN, which is mutated or homozygously deleted in numerous cancers, maps to a region of 10q within the reported region of minimal loss in bladder tumors. In two recent studies alterations in the PTEN gene occur at a low frequency in bladder tumors displaying 10q LOH. We have...

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Topics

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Share to Basic Helix-Loop-Helix Transcription Factors
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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Polymorphism, Single-Stranded Conformational

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Source

Identifiers

PMID: 11058880
DOI: 10.1002/1097-0215(20001115)88:4<620::aid-ijc16>3.0.co;2-z

Genes

PTEN
MXI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Molecular analysis of PTEN and MXI1 in primary bladder carcinoma.PMID 11058880Read ↗

Somatic mutation of PTEN in bladder carcinoma.Semantic proximity Read ↗

Frequent inactivation of PTEN in prostate cancer cell lines and xenografts.Semantic proximity Read ↗

Loss of a small region around the PTEN locus is a major chromosome 10 alteration in prostate cancer xenografts and cell lines.Semantic proximity Read ↗

Mutation of the MXI1 gene in prostate cancer.Semantic proximity Read ↗

Allelic losses on chromosome arm 10q and mutation of the PTEN (MMAC1) tumour suppressor gene in primary and metastatic malignant melanomas.Semantic proximity Read ↗

PTEN and MXI1 allelic loss on chromosome 10q is rare in melanoma in vivo.Semantic proximity Read ↗

PTEN/MMAC1 is infrequently mutated in pT2 and pT3 carcinomas of the prostate.Semantic proximity Read ↗

PTEN deletions are related to disease progression and unfavourable prognosis in early bladder cancerSemantic proximity Read ↗

<i>PTEN</i> genomic deletions that characterize aggressive prostate cancer originate close to segmental duplicationsSemantic proximity Read ↗

The MXI1 tumor suppressor gene is not mutated in primary prostate cancer.Semantic proximity Read ↗

MMAC1/PTEN mutations in primary tumor specimens and tumor cell lines.Semantic proximity Read ↗

Loss of heterozygosity in the MXI1 gene is a frequent occurrence in melanoma.Semantic proximity Read ↗

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