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Article

Regulation of the cardiac Na(+)-Ca2+ exchanger by Ca2+. Mutational analysis of the Ca(2+)-binding domain.

The Journal of general physiology - 1 Mar 1995

Matsuoka S, Nicoll D A, Hryshko L V, Levitsky D O, Weiss J N, Philipson K D

Abstract excerpt

The sarcolemmal Na(+)-Ca2+ exchanger is regulated by intracellular Ca2+ at a high affinity Ca2+ binding site separate from the Ca2+ transport site. Previous data have suggested that the Ca2+ regulatory site is located on the large intracellular loop of the Na(+)-Ca2+ exchange protein, and we have identified a high-affinity 45Ca2+ binding domain on this loop (Levitsky, D. O., D. A. Nicoll, and K. D. Philipson....

Topics

Amino Acid Sequence
Animals
Calcium
Carrier Proteins
Cytoplasm
Electric Conductivity
Molecular Sequence Data
Mutation
Oocytes
Sodium
Sodium-Calcium Exchanger

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Time Factors

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Identifiers

PMID: 7769381
DOI: 10.1085/jgp.105.3.403
PMCID: PMC2216944

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7769381-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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