Article
Regulation of the cardiac Na(+)-Ca2+ exchanger by Ca2+. Mutational analysis of the Ca(2+)-binding domain.
The Journal of general physiology - 1 Mar 1995
Matsuoka S, Nicoll D A, Hryshko L V, Levitsky D O, Weiss J N, Philipson K D
Abstract excerpt
The sarcolemmal Na(+)-Ca2+ exchanger is regulated by intracellular Ca2+ at a high affinity Ca2+ binding site separate from the Ca2+ transport site. Previous data have suggested that the Ca2+ regulatory site is located on the large intracellular loop of the Na(+)-Ca2+ exchange protein, and we have identified a high-affinity 45Ca2+ binding domain on this loop (Levitsky, D. O., D. A. Nicoll, and K. D. Philipson....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.