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Article

The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways.

Proceedings of the National Academy of Sciences of the United States of America - 30 Apr 2013

John Scott A, Liao Jun, Jiang Youxing, Ottolia Michela

Abstract excerpt

The Na(+)-Ca(2+) exchanger (NCX) is a ubiquitously expressed plasma membrane protein. It plays a fundamental role in Ca(2+) homeostasis by moving Ca(2+) out of the cell using the electrochemical gradient of Na(+) as the driving force. Recent structural studies of a homologous archaebacterial exchanger, NCX_Mj, revealed its outward configuration with two potential ion permeation pathways exposed to the...

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Identifiers

PMID: 23589872
DOI: 10.1073/pnas.1218751110
PMCID: PMC3645563

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Source receipt: pubmed, retrieved 7 Sept 2026.

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