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Article

Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger.

The Journal of biological chemistry - 29 May 2009

Chaptal Vincent, Ottolia Michela, Mercado-Besserer Gabriel, Nicoll Debora A, Philipson Kenneth D, Abramson Jeff

Abstract excerpt

The mammalian Na(+)/Ca(2+) exchanger, NCX1.1, serves as the main mechanism for Ca(2+) efflux across the sarcolemma following cardiac contraction. In addition to transporting Ca(2+), NCX1.1 activity is also strongly regulated by Ca(2+) binding to two intracellular regulatory domains, CBD1 and CBD2. The structures of both of these domains have been solved by NMR spectroscopy and x-ray crystallography, greatly...

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Identifiers

PMID: 19332552
DOI: 10.1074/jbc.C900037200
PMCID: PMC2685650

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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