Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.

Cell calcium - 1 Jun 2012

Giladi Moshe, Bohbot Hilla, Buki Tal, Schulze Dan H, Hiller Reuben, Khananshvili Daniel

Abstract excerpt

The Na(+)-Ca(2+) exchanger (NCX) mediated Ca(2+) fluxes are essential for handling Ca(2+) homeostasis in many cell-types. Eukaryotic NCX variants contain regulatory CBD1 and CBD2 domains, whereas in distinct variants the Ca(2+) binding to Ca3-Ca4 sites of CBD1 results either in sustained activation, inhibition or no effect. CBD2 contains an alternatively spliced segment, which is expressed in a tissue-specific...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Allosteric Regulation
Share to Alternative Splicing
Share to Brain Chemistry

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Calcium Signaling

Share to Kidney

Share to Protein Isoforms

Share to Sodium-Calcium Exchanger

Source

Identifiers

PMID: 22571864
DOI: 10.1016/j.ceca.2012.04.007

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.PMID 22571864Read ↗

Structure-Based Function and Regulation of NCX Variants: Updates and ChallengesSemantic proximity Read ↗

Essential role of the CBD1-CBD2 linker in slow dissociation of Ca2+ from the regulatory two-domain tandem of NCX1.Semantic proximity Read ↗

Structure-dynamic basis of splicing-dependent regulation in tissue-specific variants of the sodium-calcium exchanger.Semantic proximity Read ↗

Structure and functional analysis of a Ca2+ sensor mutant of the Na+/Ca2+ exchanger.Semantic proximity Read ↗

The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis.Semantic proximity Read ↗

Roles of two Ca2+-binding domains in regulation of the cardiac Na+-Ca2+ exchanger.Semantic proximity Read ↗

Structure-Functional Basis of Ion Transport in Sodium-Calcium Exchanger (NCX) Proteins.Semantic proximity Read ↗

The cardiac Na+-Ca2+ exchanger has two cytoplasmic ion permeation pathways.Semantic proximity Read ↗

Residues contributing to the Na(+)-binding pocket of the SLC24 Na(+)/Ca(2+)-K(+) Exchanger NCKX2.Semantic proximity Read ↗

Residues important for Ca2+ ion transport in the neuronal K+-dependent Na+-Ca2+ exchanger (NCKX2).Semantic proximity Read ↗

Characterization and functional activity of a truncated Na/Ca exchange isoform resulting from a new splicing pattern of NCX1.Semantic proximity Read ↗

Ca2+-dependent structural rearrangements within Na+-Ca2+ exchanger dimers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.