Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.

doi:10.1016/j.ceca.2012.04.007

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Article

Dynamic features of allosteric Ca2+ sensor in tissue-specific NCX variants.

Cell calcium - 1 Jun 2012

Giladi Moshe, Bohbot Hilla, Buki Tal, Schulze Dan H, Hiller Reuben, Khananshvili Daniel

Abstract excerpt

The Na(+)-Ca(2+) exchanger (NCX) mediated Ca(2+) fluxes are essential for handling Ca(2+) homeostasis in many cell-types. Eukaryotic NCX variants contain regulatory CBD1 and CBD2 domains, whereas in distinct variants the Ca(2+) binding to Ca3-Ca4 sites of CBD1 results either in sustained activation, inhibition or no effect. CBD2 contains an alternatively spliced segment, which is expressed in a tissue-specific...

Topics

Allosteric Regulation
Alternative Splicing
Amino Acid Sequence
Animals
Binding Sites
Brain Chemistry
Calcium
Calcium Signaling
Cloning, Molecular
Dogs
Drosophila Proteins
Drosophila melanogaster
Escherichia coli
Exons
Kidney

Source

Open in PubMed

Identifiers

PMID: 22571864
DOI: 10.1016/j.ceca.2012.04.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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Molecular Sequence Data

Mutation

Point Mutation