Article
Sodium-calcium exchange does not require allosteric calcium activation at high cytosolic sodium concentrations.
The Journal of physiology - 15 Sept 2006
Urbanczyk Jason, Chernysh Olga, Condrescu Madalina, Reeves John P
Abstract excerpt
The activity of the cardiac Na(+)-Ca(2+) exchanger (NCX1.1) is allosterically regulated by Ca(2+), which binds to two acidic regions in the cytosolically disposed central hydrophilic domain of the NCX protein. A mutation in one of the regulatory Ca(2+) binding regions (D447V) increases the half-activation constant (K(h)) for allosteric Ca(2+) activation from approximately 0.3 to > 1.8 microm. Chinese hamster...
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