Article
The second Ca2+-binding domain of the Na+ Ca2+ exchanger is essential for regulation: crystal structures and mutational analysis.
Proceedings of the National Academy of Sciences of the United States of America - 20 Nov 2007
Besserer Gabriel Mercado, Ottolia Michela, Nicoll Debora A, Chaptal Vincent, Cascio Duilio, Philipson Kenneth D, Abramson Jeff
Abstract excerpt
The Na(+)-Ca(2+) exchanger plays a central role in cardiac contractility by maintaining Ca(2+) homeostasis. Two Ca(2+)-binding domains, CBD1 and CBD2, located in a large intracellular loop, regulate activity of the exchanger. Ca(2+) binding to these regulatory domains activates the transport of Ca(2+) across the plasma membrane. Previously, we solved the structure of CBD1, revealing four Ca(2+) ions arranged in a...
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