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Article

Mutational analysis of the alpha-1 repeat of the cardiac Na(+)-Ca2+ exchanger.

The Journal of biological chemistry - 14 Jan 2005

Ottolia Michela, Nicoll Debora A, Philipson Kenneth D

Abstract excerpt

The Na(+)-Ca2+ exchanger contains internal regions of sequence homology known as the alpha repeats. The first region (alpha-1 repeat) includes parts of transmembrane segments (TMSs) 2 and 3 and a linker modeled to be a reentrant loop. To determine the involvement of the reentrant loop and TMS 3 portions of the alpha-1 repeat in exchanger function, we generated a series of mutants and examined ion binding and...

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Identifiers

PMID: 15519995
DOI: 10.1074/jbc.M411899200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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