Article
The T-box transcription factor Eomesodermin is essential for AVE induction in the mouse embryo.
Genes & development - 1 May 2013
Nowotschin Sonja, Costello Ita, Piliszek Anna, Kwon Gloria S, Mao Chai-an, Klein William H, Robertson Elizabeth J, Hadjantonakis Anna-Katerina
Abstract excerpt
Reciprocal inductive interactions between the embryonic and extraembryonic tissues establish the anterior-posterior (AP) axis of the early mouse embryo. The anterior visceral endoderm (AVE) signaling center emerges at the distal tip of the embryo at embryonic day 5.5 and translocates to the prospective anterior side of the embryo. The process of AVE induction and migration are poorly understood. Here we...
Topics
- Animals
- Body Patterning
- Cell Line
- Embryo, Mammalian
- Endoderm
- Gene Expression Regulation, Developmental
- LIM-Homeodomain Proteins
- Mice
- Mutation
- T-Box Domain Proteins
- Transcription Factors