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Article

Defects in tracheoesophageal and lung morphogenesis in Nkx2.1(-/-) mouse embryos.

Developmental biology - 1 May 1999

Minoo P, Su G, Drum H, Bringas P, Kimura S

Abstract excerpt

NKX2.1 is a homeodomain transcriptional factor expressed in thyroid, lung, and parts of the brain. We demonstrate that septation of the anterior foregut along the dorsoventral axis, into distinct tracheal and esophageal structures, is blocked in mouse embryos carrying a homozygous targeted disruption of the Nkx2.1 locus. This is consistent with the loss of Nkx2.1 expression, which defines the dorsoventral...

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Identifiers

PMID: 10208743
DOI: 10.1006/dbio.1999.9234

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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