nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation.

doi:10.1242/dev.124.5.1033

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Article

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation.

Development (Cambridge, England) - 1 Mar 1997

Varlet I, Collignon J, Robertson E J

Abstract excerpt

Mouse nodal, a member of the TGFbeta family of secreted growth factors is essential for gastrulation. We recently generated a nodal(lacZ) reporter allele by homologous recombination in ES cells. In the present study, beta-galactosidase staining in the perigastrulation-stage embryo has demonstrate...

Topics

Alleles
Animals
Central Nervous System
Chimera
Endoderm
Gastrula
Genotype
Mice
Nodal Protein
Proteins
Transforming Growth Factor beta
Wnt Proteins

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