Article
c-jun and multistage carcinogenesis: association of overexpression of introduced c-jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter-induced transformation.
Molecular carcinogenesis - 1 May 1995
Watts R G, Ben-Ari E T, Bernstein L R, Birrer M J, Winterstein D, Wendel E, Colburn N H
Abstract excerpt
Tumor promoters such as 12-O-tetradecanoylphorbol-13-acetate (TPA) and epidermal growth factor (EGF) induce neoplastic transformation, elevated c-jun protein expression, and activator protein-1 (AP-1)-dependent gene expression in JB6 mouse epidermal cells sensitive to tumor promoters (clone 415a P+ cells). In contrast, JB6 cells resistant to tumor promoter-induced transformation (clone 307b P- cells) exhibit a...
Topics
- Animals
- Cell Division
- Cell Transformation, Neoplastic
- Cells, Cultured
- Gene Expression
- Genes, jun
- Humans
- Mice
- Phenotype
- Proto-Oncogene Proteins c-jun