Article
A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes.
Molecular carcinogenesis - 1 Jul 1997
Dong Z, Crawford H C, Lavrovsky V, Taub D, Watts R, Matrisian L M, Colburn N H
Abstract excerpt
We previously reported that induced activator protein-1 (AP-1) transcriptional activity appears to be required for tumor promoter-induced transformation in mouse epidermal JB6 cells. To extend this investigation to a keratinocyte culture model and a transgenic mouse model, we constructed K14TAM67...
Topics
- Animals
- Anticarcinogenic Agents
- Carcinogens
- Cell Line
- Cell Transformation, Neoplastic
- Glycoproteins
- Keratinocytes
- Matrix Metalloproteinases, Membrane-Associated
- Metalloendopeptidases
- Mice
- Mutation
- NF-kappa B
- Proto-Oncogene Proteins c-jun
- RNA, Messenger
- Tetradecanoylphorbol Acetate