Article
A dominant negative mutant of jun blocking 12-O-tetradecanoylphorbol-13-acetate-induced invasion in mouse keratinocytes.
Molecular carcinogenesis - 1 Jul 1997
Dong Z, Crawford H C, Lavrovsky V, Taub D, Watts R, Matrisian L M, Colburn N H
Abstract excerpt
We previously reported that induced activator protein-1 (AP-1) transcriptional activity appears to be required for tumor promoter-induced transformation in mouse epidermal JB6 cells. To extend this investigation to a keratinocyte culture model and a transgenic mouse model, we constructed K14TAM67, a keratin 14 promoter-controlled version of the dominant negative jun mutant to directly block AP-1 activity and...
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