Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells.

Environmental health perspectives - 1 Jun 1991

Bernstein L R, Ben-Ari E T, Simek S L, Colburn N H

Abstract excerpt

The mouse epidermal JB6 cell system consists of clonal genetic variants that are sensitive (P+) or resistant (P-) to the promotion of neoplastic transformation by phorbol esters and other tumor-promoting agents. P+ cells display AP-1-dependent phorbol-ester-inducible transactivation of gene expression, whereas P- cells have a defect in transactivation. Transfection of promotion sensitivity gene pro-1 into P-...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetic Predisposition to Disease

Share to Mice, Inbred BALB C

Share to Molecular Sequence Data

Share to Phosphorylation

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 1773784
DOI: 10.1289/ehp.9193111
PMCID: PMC1568071

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells.PMID 1773784Read ↗

c-jun and multistage carcinogenesis: association of overexpression of introduced c-jun with progression toward a neoplastic endpoint in mouse JB6 cells sensitive to tumor promoter-induced transformation.Semantic proximity Read ↗

Transactivation of Fra-1 and consequent activation of AP-1 occur extracellular signal-regulated kinase dependently.Semantic proximity Read ↗

Expression of dominant negative Erk2 inhibits AP-1 transactivation and neoplastic transformation.Semantic proximity Read ↗

Grafting assay distinguishes promotion sensitive from promotion resistant JB6 cells.Semantic proximity Read ↗

Adhesion, migration, transcriptional, interferon-inducible, and other signaling molecules newly implicated in cancer susceptibility and resistance of JB6 cells by cDNA microarray analyses.Semantic proximity Read ↗

Activator protein 1 (AP-1)- and nuclear factor kappaB (NF-kappaB)-dependent transcriptional events in carcinogenesis.Semantic proximity Read ↗

Cellular Transformation and Malignancy Induced by ras Require c-junSemantic proximity Read ↗

12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells.Semantic proximity Read ↗

Differentially expressed protein Pdcd4 inhibits tumor promoter-induced neoplastic transformation.Semantic proximity Read ↗

<i>Podoplanin</i> Is a Novel Fos Target Gene in Skin CarcinogenesisSemantic proximity Read ↗

Expression of dominant negative Jun inhibits elevated AP-1 and NF-kappaB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes.Semantic proximity Read ↗

Insufficient p65 phosphorylation at S536 specifically contributes to the lack of NF-kappaB activation and transformation in resistant JB6 cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.