Article
Gene regulation and genetic susceptibility to neoplastic transformation: AP-1 and p80 expression in JB6 cells.
Environmental health perspectives - 1 Jun 1991
Bernstein L R, Ben-Ari E T, Simek S L, Colburn N H
Abstract excerpt
The mouse epidermal JB6 cell system consists of clonal genetic variants that are sensitive (P+) or resistant (P-) to the promotion of neoplastic transformation by phorbol esters and other tumor-promoting agents. P+ cells display AP-1-dependent phorbol-ester-inducible transactivation of gene expre...
Topics
- Amino Acid Sequence
- Animals
- Carcinogens
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Clone Cells
- Enhancer Elements, Genetic
- Epidermal Cells
- Gene Expression Regulation, Neoplastic
- Genetic Predisposition to Disease
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Neoplasm Proteins
- Phosphorylation
- Protein Binding
- Proto-Oncogene Proteins c-fos
- Proto-Oncogene Proteins c-jun