Article
Expression of dominant negative Jun inhibits elevated AP-1 and NF-kappaB transactivation and suppresses anchorage independent growth of HPV immortalized human keratinocytes.
Oncogene - 28 May 1998
Li J J, Rhim J S, Schlegel R, Vousden K H, Colburn N H
Abstract excerpt
AP-1 transactivation appears to be required for mouse JB6 cell neoplastic transformation induced by the tumor promoter TPA or epidermal growth factor (EGF). Exposure to AP-1 transrepressing retinoids and glucocorticoids and expression of a dominant negative c-jun (TAM67) blocked tumor promoter-in...
Topics
- Cell Division
- Cell Line
- Cell Transformation, Viral
- DNA-Binding Proteins
- Fos-Related Antigen-2
- Humans
- Keratin-14
- Keratinocytes
- Keratins
- Mutagenesis
- NF-kappa B
- Oncogene Proteins v-fos
- Oncogene Proteins, Viral
- Papillomaviridae
- Papillomavirus E7 Proteins
- Phenotype
- Promoter Regions, Genetic
- Proto-Oncogene Proteins c-fos