Article
Ultraviolet B light-induced mutagenesis of p53 hotspot codons 248 and 249 in human skin fibroblasts.
Molecular carcinogenesis - 1 Aug 1994
Amstad P, Hussain S P, Cerutti P
Abstract excerpt
Mutations in the p53 tumor suppressor gene are detected in approximately half of non-melanoma skin cancers. The type of base-pair changes observed strongly suggests solar radiation as the causative mutagen. Mutations are distributed nonrandomly and form moderate hotspots. We studied the capacity of ultraviolet B light (UVB, 280-320 nm) to induce base-pair changes into the p53 exon 7 sequence extending from nt...
Topics
- Base Sequence
- Cells, Cultured
- Codon
- Fibroblasts
- Genes, p53
- Humans
- In Vitro Techniques
- Male
- Molecular Sequence Data
- Mutation
- Skin
- Ultraviolet Rays