Article
Molecular mapping of a recombination hotspot located in the second intron of the human TAP2 locus.
American journal of human genetics - 1 Jun 1995
Cullen M, Erlich H, Klitz W, Carrington M
Abstract excerpt
Recombination across the HLA class II region is not randomly distributed, as indicated by both strong linkage disequilibrium within the 100 kb encompassing the DRB1-DQA1-DQB1 loci and complete equilibrium between TAP1 and TAP2, the closest variant sites of which are < 15 kb. In an attempt to explain these observations, 39 novel polymorphic markers in a region encompassing the TAP, LMP, and DOB genes were used to...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human
- Cloning, Molecular
- Crossing Over, Genetic
- Female
- Genes, MHC Class II
- Genetic Variation