Article
Absence of the TAP2 human recombination hotspot in chimpanzees.
PLoS biology - 1 Jun 2004
Ptak Susan E, Roeder Amy D, Stephens Matthew, Gilad Yoav, Pääbo Svante, Przeworski Molly
Abstract excerpt
Recent experiments using sperm typing have demonstrated that, in several regions of the human genome, recombination does not occur uniformly but instead is concentrated in "hotspots" of 1-2 kb. Moreover, the crossover asymmetry observed in a subset of these has led to the suggestion that hotspots may be short-lived on an evolutionary time scale. To test this possibility, we focused on a region known to contain a...
Topics
- ATP Binding Cassette Transporter, Subfamily B, Member 3
- ATP-Binding Cassette Transporters
- Animals
- Base Sequence
- Computer Simulation
- Evolution, Molecular
- Genetic Variation
- Haplotypes
- Humans
- Linkage Disequilibrium
- Models, Genetic
- Molecular Sequence Data
- Mutation