Recombination rates across the HLA complex: use of microsatellites as a rapid screen for recombinant chromosomes.

doi:10.1093/hmg/4.3.423

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Article

Recombination rates across the HLA complex: use of microsatellites as a rapid screen for recombinant chromosomes.

Human molecular genetics - 1 Mar 1995

Martin M, Mann D, Carrington M

Abstract excerpt

Meiotic recombination does not appear to occur randomly across chromosomes, but rather seems to be restricted to specific regions. A striking example of this phenomenon is illustrated by the HLA class II region. No recombination within the 100 kb encompassing the DRB1-DQA1-DQB1 loci has been repo...

Topics

Alleles
Base Sequence
Chromosome Mapping
Chromosomes, Human
DNA, Satellite
Female
Gene Frequency
HLA-D Antigens
Haplotypes
Humans
Major Histocompatibility Complex
Male
Molecular Sequence Data
Recombination, Genetic

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