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Article

Analysis of meiotic recombination in 22q11.2, a region that frequently undergoes deletions and duplications.

BMC medical genetics - 2 Apr 2007

Torres-Juan Laura, Rosell Jordi, Sánchez-de-la-Torre Manuel, Fibla Joan, Heine-Suñer Damià

Abstract excerpt

BACKGROUND: The 22q11.2 deletion syndrome is the most frequent genomic disorder with an estimated frequency of 1/4000 live births. The majority of patients (90%) have the same deletion of 3 Mb (Typically Deleted Region, TDR) that results from aberrant recombination at meiosis between region specific low-copy repeats (LCRs). METHODS: As a first step towards the characterization of recombination rates and...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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PMID: 17397557
DOI: 10.1186/1471-2350-8-14
PMCID: PMC1855045

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Analysis of meiotic recombination in 22q11.2, a region that frequently undergoes deletions and duplications.PMID 17397557Read ↗

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