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Article

Localized breakdown in linkage disequilibrium does not always predict sperm crossover hot spots in the human MHC class II region.

Genomics - 1 Jul 2005

Kauppi Liisa, Stumpf Michael P H, Jeffreys Alec J

Abstract excerpt

To investigate the relationship between meiotic crossover hot spots and block-like linkage disequilibrium (LD), we have extended our high-resolution studies of the human MHC class II region to a 90-kb segment upstream of the HLA-DOA gene. LD blocks in this region are not as well defined as in the neighboring 210-kb DNA segment but do show two regions of LD breakdown in which coalescent analysis indicates...

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Source

Identifiers

PMID: 15885980
DOI: 10.1016/j.ygeno.2005.03.011

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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