Article
Identification of novel Tapasin polymorphisms and linkage disequilibrium to MHC class I alleles.
Immunogenetics - 1 Nov 2000
Williams A P, Bevan S, Bunce M, Houlston R, Welsh K I, Elliott T
Abstract excerpt
Tapasin is a Mr 48,000 glycoprotein and has a specialized role in MHC class I-restricted antigen presentation. It is encoded by a gene which maps centromeric to the MHC class II region of human Chromosome 6 within 200 kb of HLA-DP. There is variable dependence upon tapasin for MHC class I expression among different MHC class I alleles. HLA-B*4402 and to a lesser extent HLA-A1 and B8 are tapasin dependent, whereas...
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