Article
Allelic association and recombination hotspots in the mucin gene (MUC) complex on chromosome 11p15.5.
Annals of human genetics - 1 Sept 2007
Rousseau K, Byrne C, Griesinger G, Leung A, Chung A, Hill A S, Swallow D M
Abstract excerpt
A family of four highly polymorphic genes encoding secreted gel forming mucins is located in the middle of a recombination rich region of the short arm of chromosome 11 (11p15.5; tel MUC6-MUC2-MUC5AC-MUC5B cen; approx. 400 kb). These genes are of interest as risk factors for inflammatory diseases of the epithelia, and we have for example reported association of a VNTR polymorphism of the major mucin domain of...
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