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Article

Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes.

The Journal of biological chemistry - 14 Feb 2003

Xie Yue, Zhong Rong, Chen Changmin, Calderwood Stuart K

Abstract excerpt

Heat shock factor 1 (HSF1), in addition to its pivotal role as a regulator of the heat shock response, functions as a versatile gene repressor. We have investigated the structural domains involved in gene repression using mutational analysis of the hsf1 gene. Our studies indicate that HSF1 contains two adjacent sequences located within the N-terminal half of the protein that mediate the repression of c-fos and...

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Source

Identifiers

PMID: 12468538
DOI: 10.1074/jbc.M210189200

Genes

HSF1
HSF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Heat shock factor 1 contains two functional domains that mediate transcriptional repression of the c-fos and c-fms genes.PMID 12468538Read ↗

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