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Article

Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.

British journal of clinical pharmacology - 1 Jan 1995

Liu Z, Mortimer O, Smith C A, Wolf C R, Rane A

Abstract excerpt

Ethylmorphine is metabolised by N-demethylation (to norethylmorphine) and by O-deethylation (to morphine). The O-deethylation reaction was previously shown in vivo to co-segregate with the O-demethylation of dextromethorphan indicating that ethylmorphine is a substrate of polymorphic cytochrome P450(CYP)2D6. To study further the features of ethylmorphine metabolism we investigated its N-demethylation and...

Topics

Adult
Blotting, Western
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2D6
Cytochrome P-450 CYP3A
Cytochrome P-450 Enzyme System
Ethylmorphine
Female
Humans
Male
Microsomes, Liver

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Mixed Function Oxygenases

Phenotype

Source

Open in PubMed Open full text

Identifiers

PMID: 7756104
DOI: 10.1111/j.1365-2125.1995.tb04413.x
PMCID: PMC1364985

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7756104-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Evidence for a role of cytochrome P450 2D6 and 3A4 in ethylmorphine metabolism.PMID 7756104Read ↗

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.Semantic proximity Read ↗

Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.Semantic proximity Read ↗

Urinary excretion of codeine, ethylmorphine, and their metabolites: relation to the CYP2D6 activity.Semantic proximity Read ↗

Determination of cytochrome P450 3A4/5 activity in vivo with dextromethorphan N-demethylation.Semantic proximity Read ↗

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Polymorphic formation of morphine from codeine in poor and extensive metabolizers of dextromethorphan: relationship to the presence of immunoidentified cytochrome P-450IID1.Semantic proximity Read ↗

Quantification of dextromethorphan and metabolites: a dual phenotypic marker for cytochrome P450 3A4/5 and 2D6 activity.Semantic proximity Read ↗

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