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Article

Characterization of dextromethorphan N-demethylation by human liver microsomes. Contribution of the cytochrome P450 3A (CYP3A) subfamily.

Biochemical pharmacology - 5 Jul 1994

Gorski J C, Jones D R, Wrighton S A, Hall S D

Abstract excerpt

In an effort to identify the human cytochromes P450 involved in the N-demethylation of dextromethorphan, the kinetics of 3-methoxymorphinan formation were studied in microsomal enzyme systems. Under initial rate conditions, 3-methoxymorphinan formation demonstrated single enzyme Michaelis-Menten...

Topics

Adult
Chromatography, High Pressure Liquid
Cytochrome P-450 CYP2E1
Cytochrome P-450 Enzyme Inhibitors
Cytochrome P-450 Enzyme System
Dextromethorphan
Humans
In Vitro Techniques
Kinetics
Methylation
Microsomes, Liver

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Mixed Function Oxygenases

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Identifiers

PMID: 8043020
DOI: 10.1016/0006-2952(94)90237-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8043020-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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