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Article

The consequences of 3,4-methylenedioxymethamphetamine induced CYP2D6 inhibition in humans.

Journal of clinical psychopharmacology - 1 Oct 2008

O'Mathúna Brian, Farré Magi, Rostami-Hodjegan Amin, Yang Jiansong, Cuyàs Elisabet, Torrens Marta, Pardo Ricardo, Abanades Sergio, Maluf Silvana, Tucker Geoffrey T, de la Torre Rafael

Abstract excerpt

3,4-Methylenedioxymethamphetamine (MDMA, ecstasy) is a widely abused substituted amphetamine. MDMA is predominantly O-demethylenated in humans by cytochrome P450 isoforms 2D6 and 1A2 (CYP2D6 and CYP CYP1A2, respectively). MDMA is also a mechanism-based inhibitor of CYP2D6. A controlled clinical trial was conducted in 15 healthy male subjects whereby a probe drug, dextromethorphan (DEX), was administered after an...

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PMID: 18794647
DOI: 10.1097/JCP.0b013e318184ff6e

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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