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Article

Sex differences in 3,4-methylenedioxymethamphetamine (MDMA; ecstasy)-induced cytochrome P450 2D6 inhibition in humans.

Clinical pharmacokinetics - 1 May 2011

Yubero-Lahoz Samanta, Pardo Ricardo, Farré Magí, O'Mahony Brian, Torrens Marta, Mustata Cristina, Pérez-Mañá Clara, Carbó Marcel Lí, de la Torre Rafael

Abstract excerpt

BACKGROUND AND OBJECTIVE: 3,4-Methylenedioxymethamphetamine (MDMA; ecstasy) is a ring-substituted amphetamine widely used for recreational purposes. MDMA is predominantly O-demethylenated in humans by cytochrome P450 (CYP) 2D6 and is also a potent mechanism-based inhibitor of the enzyme. This study assessed the inhibition and recovery half-life of CYP2D6 and CYP3A4 activity in female subjects by administering the...

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PMID: 21456632
DOI: 10.2165/11584550-000000000-00000

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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