The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D.

doi:10.1007/BF02265277

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Article

The murine homolog of the human breast and ovarian cancer susceptibility gene Brca1 maps to mouse chromosome 11D.

Human genetics - 1 Feb 1996

Schröck E, Badger P, Larson D, Erdos M, Wynshaw-Boris A, Ried T, Brody L

Abstract excerpt

The recently cloned human breast and ovarian cancer susceptibility gene, BRCA1, is located on human chromosome 17q21. We have isolated murine genomic clones containing Brca1 as a first step in generating a mouse model for the loss of BRCA1 function. A mouse genomic library was screened using probes corresponding to exon 11 of the human BRCA1 gene. Two overlapping mouse clones were identified that hybridized to...

Topics

Amino Acid Sequence
Animals
BRCA1 Protein
Breast Neoplasms
Chromosome Mapping
Cloning, Molecular
Female
Genetic Predisposition to Disease
Humans
In Situ Hybridization, Fluorescence
Mice
Molecular Sequence Data
Neoplasm Proteins

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

Sequence Analysis, DNA

Sequence Homology, Amino Acid

Sequence Homology, Nucleic Acid

Transcription Factors

Source

Open in PubMed

Identifiers

PMID: 8566965
DOI: 10.1007/BF02265277

Genes

BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.