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Article

Identification of a regulatory function for an orphan receptor in muscle: COUP-TF II affects the expression of the myoD gene family during myogenesis.

Nucleic acids research - 25 Apr 1995

Muscat G E, Rea S, Downes M

Abstract excerpt

COUP-TF II is an 'orphan steroid receptor' that binds a wide variety of AGGTCA repeats and represses thyroid hormone (T3) and retinoid dependent trans-activation; however, very little is known of its functional and/or developmental role during mammalian cell differentiation. T3 and retinoids have been demonstrated to promote terminal muscle differentiation via activation of the muscle specific myoD gene family...

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Identifiers

PMID: 7753622
DOI: 10.1093/nar/23.8.1311
PMCID: PMC306855

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Identification of a regulatory function for an orphan receptor in muscle: COUP-TF II affects the expression of the myoD gene family during myogenesis.PMID 7753622Read ↗

COUP-TF orphan nuclear receptors in development and differentiationSemantic proximity Read ↗

Characterization of a novel thyroid hormone receptor alpha variant involved in the regulation of myoblast differentiation.Semantic proximity Read ↗

The triiodothyronine nuclear receptor c-ErbAalpha1 inhibits avian MyoD transcriptional activity in myoblasts.Semantic proximity Read ↗

Molecular mechanism of chicken ovalbumin upstream promoter-transcription factor (COUP-TF) actionsSemantic proximity Read ↗

The nuclear orphan receptor COUP-TFII is required for limb and skeletal muscle development.Semantic proximity Read ↗

Maternal Exercise Before and During Pregnancy Facilitates Embryonic Myogenesis by Enhancing Thyroid Hormone SignalingSemantic proximity Read ↗

Identification of COUP-TFII Orphan Nuclear Receptor as a Retinoic Acid–Activated ReceptorSemantic proximity Read ↗

Inhibition of myogenic differentiation in myoblasts expressing a truncated type II TGF-β receptorSemantic proximity Read ↗

Two adjacent MyoD1-binding sites regulate expression of the acetylcholine receptor alpha-subunit gene.Semantic proximity Read ↗

TEAD transcription factors are required for normal primary myoblast differentiation in vitro and muscle regeneration in vivo.Semantic proximity Read ↗

A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity.Semantic proximity Read ↗

Repression of myogenin function by TGF-beta 1 is targeted at the basic helix-loop-helix motif and is independent of E2A products.Semantic proximity Read ↗

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