Article
A splice variant of the ITF-2 transcript encodes a transcription factor that inhibits MyoD activity.
The Journal of biological chemistry - 16 Feb 1996
Skerjanc I S, Truong J, Filion P, McBurney M W
Abstract excerpt
Proteins of the basic helix-loop-helix (bHLH) family are transcription factors that bind DNA containing the E box motif (CANNTG) found in the promoters of many muscle-specific genes. ITF-2 is a bHLH protein with widespread expression that is thought to form active heterodimers with MyoD, a muscle-specific bHLH transcription factor. We have isolated cDNAs derived from two alternatively spliced forms of mouse...
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