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Article

Loss of LKLF function results in embryonic lethality in mice.

Transgenic research - 1 Jul 1998

Wani M A, Means R T, Lingrel J B

Abstract excerpt

Lung Kruppel-like factor (LKLF) is a member of the Kruppel-like family of zinc finger transcription factors and is closely related to erythroid kruppel-like factor (EKLF), which is necessary for beta-globin gene expression. While EKLF is expressed exclusively in erythroid cells, LKLF is expressed temporally during early embryonic development and predominantly in the adult mouse lung. To understand the role this...

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Source

Identifiers

PMID: 9859212
DOI: 10.1023/a:1008809809843

Genes

GATA1
GATA3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of LKLF function results in embryonic lethality in mice.PMID 9859212Read ↗

Lung Kruppel-like factor, a zinc finger transcription factor, is essential for normal lung development.Semantic proximity Read ↗

The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.Semantic proximity Read ↗

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivoSemantic proximity Read ↗

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression.Semantic proximity Read ↗

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

Novel role for EKLF in megakaryocyte lineage commitmentSemantic proximity Read ↗

Severe anemia in the Nan mutant mouse caused by sequence-selective disruption of erythroid Kruppel-like factor.Semantic proximity Read ↗

Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)Semantic proximity Read ↗

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.Semantic proximity Read ↗

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.Semantic proximity Read ↗

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.Semantic proximity Read ↗

Developmental regulation of yolk sac hematopoiesis by Kruppel-like factor 6.Semantic proximity Read ↗

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