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Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene Switching

1 Jan 1995

Abstract excerpt

Erythroid Kruppel-like factor (EKLF) is an erythroid-specific transcription factor that contains zinc finger domains similar to the Kruppel protein of Drosophila melanogaster. Previous studies demonstrated that EKLF binds to the CACCC box in the human beta-globin gene promoter and activates transcription. CACCC box mutations that cause severe beta-thalassemias in humans inhibit EKLF binding. Results described in...

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PMID: 7829533
DOI: 10.1074/jbc.270.4.1955

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Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene SwitchingPMID 7829533Read ↗

Isolation, Genomic Structure, and Expression of Human Erythroid Krüppel-Like Factor (EKLF)Semantic proximity Read ↗

FKLF, a Novel Krüppel-Like Factor That Activates Human Embryonic and Fetal β-Like Globin GenesSemantic proximity Read ↗

Recombinant erythroid Kruppel-like factor fused to GATA1 up-regulates delta- and gamma-globin expression in erythroid cellsSemantic proximity Read ↗

Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.Semantic proximity Read ↗

Krüppel-Like Factor 1: A Pivotal Gene Regulator in ErythropoiesisSemantic proximity Read ↗

Erythroid Krüppel-like factor (EKLF) is active in primitive and definitive erythroid cells and is required for the function of 5'HS3 of the beta-globin locus control region.Semantic proximity Read ↗

Downregulation of KLF4 activates embryonic and fetal globin mRNA expression in human erythroid progenitor cellsSemantic proximity Read ↗

Lethal beta-thalassaemia in mice lacking the erythroid CACCC-transcription factor EKLF.Semantic proximity Read ↗

Erythroid Kruppel‐like factor (EKLF) is recruited to the <i>γ</i>‐<i>globin</i> gene promoter as a co‐activator and is required for <i>γ</i>‐<i>globin</i> gene induction by short‐chain fatty acid derivativesSemantic proximity Read ↗

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivoSemantic proximity Read ↗

The GATA-E box-GATA motif in the EKLF promoter is required for in vivo expression.Semantic proximity Read ↗

Erythroid Krüppel-Like Factor (KLF1): A Surprisingly Versatile Regulator of Erythroid Differentiation.Semantic proximity Read ↗

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