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Article

KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivo

10 Jun 2005

Abstract excerpt

The Krüppel-like factors (KLFs) are a family of C2/H2 zinc finger DNA-binding proteins that are important in controlling developmental programs. Erythroid Krüppel-like factor (EKLF or KLF1) positively regulates the beta-globin gene in definitive erythroid cells. KLF2 (LKLF) is closely related to EKLF and is expressed in erythroid cells. KLF2-/- mice die between embryonic day 12.5 (E12.5) and E14.5, because of...

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Identifiers

PMID: 15947087
DOI: 10.1182/blood-2005-02-0674

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KLF2 is essential for primitive erythropoiesis and regulates the human and murine embryonic β-like globin genes in vivoPMID 15947087Read ↗

Krüppel-like transcription factors KLF1 and KLF2 have unique and coordinate roles in regulating embryonic erythroid precursor maturation.Semantic proximity Read ↗

The erythroid phenotype of EKLF-null mice: defects in hemoglobin metabolism and membrane stability.Semantic proximity Read ↗

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Downregulation of KLF4 activates embryonic and fetal globin mRNA expression in human erythroid progenitor cellsSemantic proximity Read ↗

FKLF, a Novel Krüppel-Like Factor That Activates Human Embryonic and Fetal β-Like Globin GenesSemantic proximity Read ↗

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Silencing of human fetal globin expression is impaired in the absence of the adult beta-globin gene activator protein EKLF.Semantic proximity Read ↗

Role of Erythroid Kruppel-like Factor in Human γ- to β-Globin Gene SwitchingSemantic proximity Read ↗

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